An Enzymatic Toolbox for Cascade Reactions: A Showcase for an In Vivo Redox Sequence in Asymmetric Synthesis. Issue 12 (13th September 2013)

• Record Type: Journal Article
• Authors: Oberleitner, Nikolin; Peters, Christin; Muschiol, Jan; Kadow, Maria; Saß, Stefan; Bayer, Thomas; Schaaf, Patricia; Iqbal, Naseem; Rudroff, Florian; Mihovilovic, Marko D.; Bornscheuer, Uwe T.
• Is Part Of: ChemCatChem. Volume 5:Issue 12(2013:Dec.)
• Page Start: 3524
• Page End: 3528
• Publication Date: 2013-09-13
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201300604
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Joined forces:</bold> Alcohol dehydrogenase, enoate reductase, and Baeyer–Villiger monooxygenase are combined in a cascade reaction by coexpression in <italic>E. coli</italic> to have a recombinant whole‐cell biocatalyst. Such an artificial metabolic "mini"‐pathway provides access to functionalized chiral compounds in high yields and optical purities as exemplified for kinetic resolutions, desymmetrizations, and regiodivergent biotransformations.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7hh5mv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>