On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle‐Dependant Manner. Issue 3 (16th January 2014)

• Record Type: Journal Article
• Authors: Stocker, Bridget L.; Khan, Ashna A.; Chee, Stephanie H.; Kamena, Faustin; Timmer, Mattie S. M.
• Is Part Of: Chembiochem. Volume 15:Issue 3(2014)
• Page Start: 382
• Page End: 388
• Publication Date: 2014-01-16
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300674
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The C₂₂ and C₂₆ trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a Mincle‐dependent manner. The activities of the monoesters paralleled those of their diester counterparts, and both mono‐ and diesters could activate the immune response in the absence of priming. This is the first time that trehalose monoesters have been found to activate macrophages, and these studies thus provide an important framework for the rational design of other Mincle agonists.</p> </abstract>