Effect of Stereochemistry of Avermectin‐Like 6, 6‐Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius. Issue 5 (26th February 2014)

• Record Type: Journal Article
• Authors: Sun, Peng; Zhao, Qunfei; Zhang, Hua; Wu, Jiequn; Liu, Wen
• Is Part Of: Chembiochem. Volume 15:Issue 5(2014)
• Page Start: 660
• Page End: 664
• Publication Date: 2014-02-26
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300616
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Natural avermectins (AVEs) share a 6, 6‐spiroketal moiety with an exclusive <italic>R</italic> configuration at the C21 spirocyclic junction. Herein, we report the characterization of nine AVE‐like spiroketals of two types (C21 <italic>S</italic> and <italic>R</italic>) in a mutant strain that lacks spirocyclase activity. Comparative analysis of their structures facilitated evaluation of the effect of stereochemistry on endogenous biotransformations and biological activities of the spiroketals.</p> </abstract>