Macromolecular Uptake of Alkyl‐Chain‐Modified Guanidinoglycoside Molecular Transporters. Issue 5 (20th February 2014)

• Record Type: Journal Article
• Authors: Inoue, Makoto; Wexselblatt, Ezequiel; Esko, Jeffrey D.; Tor, Yitzhak
• Is Part Of: Chembiochem. Volume 15:Issue 5(2014)
• Page Start: 676
• Page End: 680
• Publication Date: 2014-02-20
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300606
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Guanidinoglycosides, a family of cellular transporters capable of delivering high <italic>M</italic>_w biopolymers, have previously been shown to display high selectivity for cell‐surface heparan sulfate proteoglycans and promote their clustering. Herein, the internalization mechanism of amphiphilic guanidinoglycoside derivatives was investigated by cell‐surface FRET analysis. Unexpectedly, although the heparan sulfate selectivity is maintained, the cellular uptake of these derivatives does not appear to involve clustering of the proteoglycans on the cell surface. This suggests a distinct uptake mechanism when compared to the parent guanidinoglycoside‐based carriers.</p> </abstract>