A Simple Strategy for Glycosyltransferase‐Catalyzed Aminosugar Nucleotide Synthesis. Issue 5 (20th February 2014)

• Record Type: Journal Article
• Authors: Zhang, Jianjun; Singh, Shanteri; Hughes, Ryan R.; Zhou, Maoquan; Sunkara, Manjula; Morris, Andrew J.; Thorson, Jon S.
• Is Part Of: Chembiochem. Volume 15:Issue 5(2014)
• Page Start: 647
• Page End: 651
• Publication Date: 2014-02-20
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300779
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A set of 2‐chloro‐4‐nitrophenyl glucosamino‐/xylosaminosides were synthesized and assessed as potential substrates in the context of glycosyltransferase‐catalyzed formation of the corresponding UDP/TDP‐α‐<sc>D</sc>‐glucosamino‐/xylosaminosugars and in single‐vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki to be a proficient catalyst for U/TDP‐aminosugar synthesis and utilization.</p> </abstract>