Cover Picture: Synthesis and Characterization of Cell‐Permeable Caged Phosphates that Can Be Photolyzed by Visible Light or 800 nm Two‐Photon Photolysis (ChemBioChem 17/2013). Issue 17 (25th November 2013)

• Record Type: Journal Article
• Authors: Herbivo, Cyril; Omran, Ziad; Revol, Julia; Javot, Hélène; Specht, Alexandre
• Is Part Of: Chembiochem. Volume 14:Issue 17(2013)
• Page Start: 2221
• Page End: 2221
• Publication Date: 2013-11-25
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201390062
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The cover picture shows a membrane‐permeable photolabile precursor of inorganic phosphate (Pi). The EANBP caged‐Pi molecules can accumulate intracellularly by using acetoxymethyl (AM) groups for cell delivery. This principle is schematically represented here, as applied to root‐tip cells from the plant <italic>Arabidopsis thaliana.</italic> The caged‐Pi molecule is able to release Pi efficiently, either after visible light irradiation, or after two‐photon excitation at 800 nm. Altogether, this membrane‐permeable caged Pi allows the generation and maintenance of a considerable pool of intracellular Pi, thus making it suitable for the study of the Pi signal‐transduction cascade in living cells, including plant cells. For further information, see the paper by H. Javot, A. Specht, et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 2277 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t78w33q" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>