Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining. Issue 16 (17th September 2013)

• Record Type: Journal Article
• Authors: Awakawa, Takayoshi; Yang, Xiao‐Long; Wakimoto, Toshiyuki; Abe, Ikuro
• Is Part Of: Chembiochem. Volume 14:Issue 16(2013)
• Page Start: 2095
• Page End: 2099
• Publication Date: 2013-09-17
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300430
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Induced production of PKS‐NRPS metabolites</bold>: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in <italic>Aspergillus niger</italic> ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t78rm0w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>