Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity. Issue 18 (31st October 2013)

• Record Type: Journal Article
• Authors: Gau, Benjamin; Lemétais, Aurélie; Lepore, Marco; Garcia‐Alles, Luis Fernando; Bourdreux, Yann; Mori, Lucia; Gilleron, Martine; De Libero, Gennaro; Puzo, Germain; Beau, Jean‐Marie; Prandi, Jacques
• Is Part Of: Chembiochem. Volume 14:Issue 18(2013)
• Page Start: 2413
• Page End: 2417
• Publication Date: 2013-10-31
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300482
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The longer, the better</bold>: Increasing the lengths of the 1, 3‐methyl‐branched fatty acyl chain units in mycobacterial diacylated sulfoglycolipid (Acyl₂SGL) analogues led to dramatic improvements in their antigenic properties and gave products more potent than the natural antigen Acyl₂SGLs.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3m3gcj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>