Biocatalytic Synthesis of Quercetin 3‐O‐Glucoside‐7‐O‐Rhamnoside by Metabolic Engineering of Escherichia coli. Issue 18 (6th November 2013)

• Record Type: Journal Article
• Authors: Roepke, Jonathon; Bozzo, Gale G.
• Is Part Of: Chembiochem. Volume 14:Issue 18(2013)
• Page Start: 2418
• Page End: 2422
• Publication Date: 2013-11-06
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201300474
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>You are what you eat:</bold> Quercetin 3‐<italic>O</italic>‐glucoside‐7‐<italic>O</italic>‐rhamnoside is a rare natural product with potential biological importance. We describe a strategy for the regioselective synthesis of this bisglycoside by feeding quercetin 3‐<italic>O</italic>‐glucoside, a naturally abundant precursor, to metabolically engineered <italic>Escherichia coli.</italic><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3m3f5q" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>