First use of 18F‐labeled ML‐10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy. Issue 2 (12th February 2014)

• Record Type: Journal Article
• Authors: Oborski, Matthew J.; Laymon, Charles M.; Lieberman, Frank S.; Drappatz, Jan; Hamilton, Ronald L.; Mountz, James M.
• Is Part Of: Brain and behavior. Volume 4:Issue 2(2014:Mar.)
• Page Start: 312
• Page End: 315
• Publication Date: 2014-02-12
• Subjects: Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.217
• Languages: English
• ISSNs: 2162-3279

Abstract

<abstract abstract-type="main" id="brb3217-abs-0001"> <title>Abstract</title> <sec id="brb3217-sec-0001" sec-type="section"> <title>Objectives</title> <p>The authors present the first use of the novel positron emission tomography (PET) apoptosis tracer <sup>18</sup>F‐labeled 2‐(5‐fluoro‐pentyl)‐2‐methyl‐malonic acid (<sup>18</sup>F‐ML‐10) for early‐therapy response assessment of a newly diagnosed glioblastoma multiforme (GBM) patient.</p> </sec> <sec id="brb3217-sec-0002" sec-type="section"> <title>Case report</title> <p>A 71‐year‐old male with a newly diagnosed GBM received <sup>18</sup>F‐ML‐10 PET scans prior to therapy initiation (baseline) and after completing 3 weeks of whole‐brain radiation therapy with concomitant temozolomide chemotherapy (early‐therapy assessment, ETA). The baseline <sup>18</sup>F‐ML‐10 PET scan showed increased tracer uptake at the site of the GBM, with highest activity toward the central portion of the tumor. At the ETA time point, a new distribution of tracer uptake was observed compared to baseline. Normalized pixel‐by‐pixel subtraction of baseline from ETA was used to quantify change in tracer distribution between <sup>18</sup>F‐ML‐10 PET imaging time points. Results of this analysis showed reduction in <sup>18</sup>F‐ML‐10 uptake at the site of greatest baseline uptake, but increased uptake around the periphery of the tumor at the early‐therapy time point.</p> </sec> <sec id="brb3217-sec-0003" sec-type="section"> <title>Conclusion</title> <p>The changing patterns of <sup>18</sup>F‐ML‐10 uptake between baseline and ETA are suggestive for therapy‐induced tumor cellular apoptosis.</p> </sec> </abstract>