A Fluorogenic Probe with Aggregation‐Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers. Issue 3 (8th January 2014)

• Record Type: Journal Article
• Authors: Wang, Xiaojing; Liu, Huan; Li, Jingwen; Ding, Kaiguo; Lv, Zhonglin; Yang, Yonggang; Chen, Hong; Li, Xinming
• Is Part Of: Chemistry, an Asian journal. Volume 9:Issue 3(2014:Mar.)
• Page Start: 784
• Page End: 789
• Publication Date: 2014-01-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201301326
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Herein, we report a novel fluorescent "light‐up" probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into supramolecular microfibers, thus giving rise to "turn‐on" fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 p<sc>M</sc>, which is much lower than the corresponding assays based on other fluorescent approaches.</p> </abstract>