Bicyclic‐Guanidine‐Catalyzed Asymmetric Michael Addition of 3‐Substituted Oxindoles to 2‐Cyclopentenone. Issue 12 (20th September 2013)

• Record Type: Journal Article
• Authors: Yang, Caiyun; Chen, Wenchao; Yang, Wenguo; Zhu, Bo; Yan, Lin; Tan, Choon‐Hong; Jiang, Zhiyong
• Is Part Of: Chemistry, an Asian journal. Volume 8:Issue 12(2013:Dec.)
• Page Start: 2960
• Page End: 2964
• Publication Date: 2013-09-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201301011
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Taking the Michael</bold>: The first highly enantio‐ and diastereoselective Michael addition of various 3‐benzyl‐substituted oxindoles to 2‐cyclopentenone has been developed. A variety of 3, 3‐disubstituted oxindoles as Michael adducts were obtained in 69–99 % yield with 73–98 % <italic>ee</italic> and 9:1 to &gt;20:1 d.r.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t792tmq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>