Back Cover: Biomimetic RNA‐Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells (Angew. Chem. Int. Ed. 7/2014). Issue 7 (20th January 2014)

• Record Type: Journal Article
• Authors: Wang, Zhongliang; Wang, Zhe; Liu, Dingbin; Yan, Xuefeng; Wang, Fu; Niu, Gang; Yang, Min; Chen, Xiaoyuan
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 7(2014)
• Page Start: 2004
• Page End: 2004
• Publication Date: 2014-01-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201400197
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Synthetic RISC‐mimic nanocomplexes for sequence‐specific gene silencing are demonstrated by X. Chen, M. Yang, et al. in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 1997 ff.</ext-link> Owing to unusual cooperative interaction among the components, the nanocomplexes, which were designed to target multidrug resistance, are able to successfully restore the sensitivity of OVCAR8/ADR cells to Pgp‐transportable cytotoxic agents, and also exhibit resistance to enzymatic degradation, excellent target selectivity, and specific self‐delivery.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sm9qcrj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>