Inside Back Cover: Controlling Biological Activity with Light: Diarylethene‐Containing Cyclic Peptidomimetics (Angew. Chem. Int. Ed. 13/2014). Issue 13 (24th February 2014)

• Record Type: Journal Article
• Authors: Babii, Oleg; Afonin, Sergii; Berditsch, Marina; Reiβer, Sabine; Mykhailiuk, Pavel K.; Kubyshkin, Vladimir S.; Steinbrecher, Thomas; Ulrich, Anne S.; Komarov, Igor V.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 13(2014)
• Page Start: 3519
• Page End: 3519
• Publication Date: 2014-02-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201401081
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A photoswitchable analogue of the cyclic antimicrobial peptide gramicidin S was created by using a reversibly photoisomerizable diarylethene scaffold. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 3392 ff., </ext-link> A S. Ulrich, I V. Komarov, and co‐workers show that the biological activity of the resulting peptidomimetic could be effectively controlled by ultraviolet/visible light, as illustrated by a bacterial lawn treated with the modified gramicidin S and illuminated through a mask.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t07dtw5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>