Palladium‐Catalyzed CS Activation/Aryne Insertion/Coupling Sequence: Synthesis of Functionalized 2‐Quinolinones1. Issue 13 (20th February 2014)

• Record Type: Journal Article
• Authors: Dong, Ying; Liu, Bangyu; Chen, Peng; Liu, Qun; Wang, Mang
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 13(2014)
• Page Start: 3442
• Page End: 3446
• Publication Date: 2014-02-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201310340
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The insertion of an aryne into a CS bond can suppress the addition of an S nucleophile to the aryne in the presence of palladium. Catalyzed by Pd(OAc)₂, a wide range of α‐carbamoyl ketene dithioacetals readily react with arynes to selectively afford functionalized 2‐quinolinones in high yields under neutral reaction conditions by a CS activation/aryne insertion/intramolecular coupling sequence. The attractive feature of the new strategy also lies in the versatile transformations of the alkythio‐substituted quinolinone products.</p> </abstract>