Inside Back Cover: Structure‐Based Design of an RNA‐Binding p‐Terphenylene Scaffold that Inhibits HIV‐1 Rev Protein Function (Angew. Chem. Int. Ed. 50/2013). Issue 50 (25th November 2013)

• Record Type: Journal Article
• Authors: González‐Bulnes, Luis; Ibáñez, Ignacio; Bedoya, Luis M.; Beltrán, Manuela; Catalán, Silvia; Alcamí, José; Fustero, Santos; Gallego, José
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 50(2013)
• Page Start: 13477
• Page End: 13477
• Publication Date: 2013-11-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201309856
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Bilaterally substituted p‐terphenyl molecules reproduce the interactions of an α‐helix of the HIV‐1 protein Rev with its RNA receptor and block Rev function and virus replication. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 13405 ff., </ext-link> J. Alcamí, S. Fustero, and J. Gallego et al. report the structure‐based design of <italic>p</italic>‐terphenyl molecules that inhibit the Rev‐mediated transport of HIV‐1 RNA from the nucleus to the cytoplasm by binding to the RNA loop that is recognized by Rev (image prepared with the help of M.C. Ibáñez).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3kjxxx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>