Sequence Control in Polymer Chemistry through the Passerini Three‐Component Reaction1. Issue 3 (4th December 2013)

• Record Type: Journal Article
• Authors: Solleder, Susanne C.; Meier, Michael A. R.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 3(2014)
• Page Start: 711
• Page End: 714
• Publication Date: 2013-12-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201308960
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new strategy to achieve sequence control in polymer chemistry based on the iterative application of the versatile Passerini three‐component reaction (P‐3CR) in combination with efficient thiol–ene addition reactions is introduced. First, stearic acid was used as a starting substrate to build up a sequence‐defined tetramer with a molecular weight of 1.6 kDa. Using an acid‐functionalized PEG allowed for an easier isolation of the sequence‐defined macromolecules by simple precipitation and led to a sequence‐defined pentamer in a block‐copolymer architecture. Importantly, this new strategy completely avoids protecting group chemistry. By following this strategy, a different side chain can be introduced to the polymer/oligomer backbone in a simple way and at a defined position within the macromolecule.</p> </abstract>