A Common Origin for Guanidinobutanoate Starter Units in Antifungal Natural Products1. Issue 49 (11th November 2013)

• Record Type: Journal Article
• Authors: Hong, Hui; Fill, Taicia; Leadlay, Peter F.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 49(2013)
• Page Start: 13096
• Page End: 13099
• Publication Date: 2013-11-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201308136
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Keeping it basic</bold>: Arginine provides the exotic 4‐guanidinobutanoate starter unit for two different types of zwitterionic polyketide (an example for one type is shown in the picture) produced by the same <italic>Streptomyces</italic> bacterium. The three‐step precursor pathway is initiated by a remarkable decarboxylating monooxygenase with high specificity for arginine.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7b02px" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>