Back Cover: Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3 (Angew. Chem. Int. Ed. 44/2013). Issue 44 (2nd October 2013)

• Record Type: Journal Article
• Authors: Neubauer, Stefanie; Rechenmacher, Florian; Beer, Ambros J.; Curnis, Flavio; Pohle, Karolin; D'Alessandria, Calogero; Wester, Hans‐Jürgen; Reuning, Ute; Corti, Angelo; Schwaiger, Markus; Kessler, Horst
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 44(2013)
• Page Start: 11666
• Page End: 11666
• Publication Date: 2013-10-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201308315
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>In vivo tumor imaging</bold> by positron emission tomography (PET) is possible following the functionalization of α5β1 or αvβ3 subtype‐selective integrin antagonists with NODAGA. H. Kessler and co‐workers also show in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 11656 ff.</ext-link> that these peptidomimetics are able to block bFGF‐ and VEGF‐stimulated angiogenesis in a rat aortic ring (RAR) assay, and exert anti‐tumor effects in a fibrosarcoma model in mice. (Picture designed by Philipp Ganthaler.)<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6z7pv1" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>