A Dendritic Thioester Hydrogel Based on Thiol–Thioester Exchange as a Dissolvable Sealant System for Wound Closure1. Issue 52 (26th November 2013)

• Record Type: Journal Article
• Authors: Ghobril, Cynthia; Charoen, Kristie; Rodriguez, Edward K.; Nazarian, Ara; Grinstaff, Mark W.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 52(2013)
• Page Start: 14070
• Page End: 14074
• Publication Date: 2013-11-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201308007
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Washable wound dressing</bold>: A dissolvable dendritic thioester hydrogel for wound closure has been developed. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. This material can be washed off upon exposure to thiolates because a thiol–thioester exchange takes place, and gradual wound re‐exposure may be achieved during surgical care.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3hxjct" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>