Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling1. Issue 49 (21st October 2013)

• Record Type: Journal Article
• Authors: Narayan, Rishikesh; Bauer, Jonathan O.; Strohmann, Carsten; Antonchick, Andrey P.; Waldmann, Herbert
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 49(2013)
• Page Start: 12892
• Page End: 12896
• Publication Date: 2013-10-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201307392
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Dipolar cycloaddition</bold>: A highly efficient copper(I)‐catalyzed enantioselective [3+2] cycloaddition reaction of 1, 3‐fused cyclic azomethine ylides and nitroalkenes has been developed. This method provides access to functionalized tropane scaffolds with several quaternary and tertiary stereocenters in a single step under mild reaction conditions.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7b016p" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>