Scalable Synthesis of Oxazolones from Propargylic Alcohols through Multistep Palladium(II) Catalysis: β‐Selective Oxidative Heck Coupling of Cyclic Sulfonyl Enamides and Aryl Boroxines1. Issue 51 (31st October 2013) - Alamsetti, Santosh Kumar
Abstract A whale of a scale: The title oxidative Heck coupling proceeded with unusual β selectivity to generate a variety of branched substituted oxazolones (see scheme; Ts=p‐toluenesulfonyl). The three‐step synthesis from readily available starting materials with a simple palladium catalyst and inexpensive reagents could be carried out in a single reaction vessel or scaled up for the preparation of large amounts of these amino acid precursors.