A Metal‐Free Multicomponent Cascade Reaction for the Regiospecific Synthesis of 1, 5‐Disubstituted 1, 2, 3‐Triazoles1. Issue 50 (13th November 2013)

• Record Type: Journal Article
• Authors: Cheng, Guolin; Zeng, Xiaobao; Shen, Jinhai; Wang, Xuesong; Cui, Xiuling
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 50(2013)
• Page Start: 13265
• Page End: 13268
• Publication Date: 2013-11-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201307499
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>About specifics</bold>: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α‐amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4‐toluenesulfonyl).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3kjz4r" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>