Divergent Total Synthesis of Indoxamycins A, C, and F1. Issue 50 (31st October 2013) - He, Chi
Abstract The concise and divergent total synthesis of (−)‐indoxamycins A, C, and F has been completed for the first time by using a tricyclic enone as the common late‐stage intermediate. The key steps of the strategy are based on an Ireland–Claisen rearrangement, a stereodivergent reductive 1, 6‐enyne cyclization, and a tandem 1, 2‐addition/oxa‐Michael/methylenation reaction.