Detection and Characterization of 1, 2‐Dibromoethane‐Derived DNA Crosslinks Formed with O6‐Alkylguanine‐DNA Alkyltransferase1. Issue 49 (15th October 2013)

• Record Type: Journal Article
• Authors: Chowdhury, Goutam; Cho, Sung‐Hee; Pegg, Anthony E.; Guengerich, F. Peter
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 49(2013)
• Page Start: 12879
• Page End: 12882
• Publication Date: 2013-10-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201307580
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A combination</bold> of chemical modifications and LC‐tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with <italic>O</italic>⁶‐alkylguanine‐DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA–protein crosslinks is necessary to understand mechanisms of mutagenesis.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7b0cfq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>