Exploiting Protein Symmetry To Design Light‐Controllable Enzyme Inhibitors1. Issue 2 (25th November 2013)
- Record Type:
- Journal Article
- Title:
- Exploiting Protein Symmetry To Design Light‐Controllable Enzyme Inhibitors1. Issue 2 (25th November 2013)
- Main Title:
- Exploiting Protein Symmetry To Design Light‐Controllable Enzyme Inhibitors1
- Authors:
- Reisinger, Bernd
Kuzmanovic, Natascha
Löffler, Patrick
Merkl, Rainer
König, Burkhard
Sterner, Reinhard - Abstract:
- <abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The activity of the metabolic branch‐point enzyme PriA from <italic>Mycobacterium tuberculosis</italic> (<italic>mt</italic>PriA) can be controlled reversibly by light. Two‐pronged inhibitors based on the dithienylethene scaffold were designed utilizing <italic>mt</italic>PriA's natural rotational symmetry. Switching from the flexible, ring‐open to the rigid, ring‐closed isomer reduces inhibition activity by one order of magnitude.</p> </abstract>
- Is Part Of:
- Angewandte Chemie international edition. Volume 53:Issue 2(2014)
- Journal:
- Angewandte Chemie international edition
- Issue:
- Volume 53:Issue 2(2014)
- Issue Display:
- Volume 53, Issue 2 (2014)
- Year:
- 2014
- Volume:
- 53
- Issue:
- 2
- Issue Sort Value:
- 2014-0053-0002-0000
- Page Start:
- 595
- Page End:
- 598
- Publication Date:
- 2013-11-25
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773 ↗
http://www.interscience.wiley.com/jpages/1433-7851 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/anie.201307207 ↗
- Languages:
- English
- ISSNs:
- 1433-7851
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000500
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 3745.xml