An Iron/Amine‐Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols1. Issue 49 (15th October 2013)

• Record Type: Journal Article
• Authors: Quintard, Adrien; Constantieux, Thierry; Rodriguez, Jean
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 49(2013)
• Page Start: 12883
• Page End: 12887
• Publication Date: 2013-10-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201307295
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Three is a lucky number</bold>: An enantioselective transformation of allylic alcohols into β‐chiral saturated alcohols has been developed by combining two distinct metal‐ and organocatalyzed catalytic cycles. This waste‐free triple cascade process merges an iron‐catalyzed borrowing‐hydrogen step with an aminocatalyzed nucleophilic addition reaction.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t79zzj7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>