A Redox‐Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States1. Issue 52 (12th November 2013)

• Record Type: Journal Article
• Authors: Tsitovich, Pavel B.; Spernyak, Joseph A.; Morrow, Janet R.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 52(2013)
• Page Start: 13997
• Page End: 14000
• Publication Date: 2013-11-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201306394
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Trigger ready</bold>: A redox‐activated MRI contrast agent can cycle between paramagnetic Co^II (MRI‐active) and diamagnetic Co^III (MRI‐silent). The paramagnetic Co^II form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O₂ partial pressure and reductant concentration (thiols) on a time scale relevant to imaging. MT=magnetization transfer.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3hxh1s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>