Copper‐Mediated Synthesis of 1, 2, 3‐Triazoles from N‐Tosylhydrazones and Anilines1. Issue 50 (15th October 2013)

• Record Type: Journal Article
• Authors: Chen, Zhengkai; Yan, Qiangqiang; Liu, Zhanxiang; Xu, Yiming; Zhang, Yuhong
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 50(2013)
• Page Start: 13324
• Page End: 13328
• Publication Date: 2013-10-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201306416
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>NNNifty targets</bold>: In a straightforward copper‐mediated synthesis of 1, 4‐disubstituted and 1, 4, 5‐trisubstituted 1, 2, 3‐triazoles, readily available aniline and <italic>N</italic>‐tosylhydrazone substrates underwent cyclization through CN and NN bond formation (see scheme; Piv=pivaloyl, Ts=<italic>p</italic>‐toluenesulfonyl). This method enables the preparation of 1, 2, 3‐triazoles with high efficiency under mild conditions without the use of azides.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3kjw58" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>