A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell1. Issue 50 (18th October 2013)

• Record Type: Journal Article
• Authors: Han, Le; Pandian, Ganesh N.; Junetha, Syed; Sato, Shinsuke; Anandhakumar, Chandran; Taniguchi, Junichi; Saha, Abhijit; Bando, Toshikazu; Nagase, Hiroki; Sugiyama, Hiroshi
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 50(2013)
• Page Start: 13410
• Page End: 13413
• Publication Date: 2013-10-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201306766
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Germ cell gene switch</bold>: The dynamic epigenome coordinates the timely genome‐wide transcriptional activation that governs interindividual diversity, for example, in germ cells, which differ from somatic cells through their ability to undergo meiosis. Now, an epigenetically active synthetic small molecule can trigger unusual activation of the typically conserved PIWI gene that regulates the meiotic process in a human somatic cell.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3kk4mj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>