A Practical Access to Highly Enantiomerically Pure Flavanones by Catalytic Asymmetric Transfer Hydrogenation. Issue 44 (11th September 2013)

• Record Type: Journal Article
• Authors: Lemke, Marie‐Kristin; Schwab, Pia; Fischer, Petra; Tischer, Sandra; Witt, Morris; Noehringer, Laurence; Rogachev, Victor; Jäger, Anne; Kataeva, Olga; Fröhlich, Roland; Metz, Peter
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 44(2013)
• Page Start: 11651
• Page End: 11655
• Publication Date: 2013-09-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201306500
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A surprisingly selective</bold>, non‐enzymatic kinetic resolution of readily available, racemic β‐chiral ketones enabled the title process, which was applied to a rapid synthesis of several bioactive flavanones in virtually enantiopure form (see scheme; MOM=methoxymethyl, Ts=<italic>p</italic>‐toluenesulfonyl).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6z7z31" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>