Real‐Time In Situ Powder X‐ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals1. Issue 44 (23rd September 2013)

• Record Type: Journal Article
• Authors: Halasz, Ivan; Puškarić, Andreas; Kimber, Simon A. J.; Beldon, Patrick J.; Belenguer, Ana M.; Adams, Frank; Honkimäki, Veijo; Dinnebier, Robert E.; Patel, Bhavnita; Jones, William; Štrukil, Vjekoslav; Friščić, Tomislav
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 44(2013)
• Page Start: 11538
• Page End: 11541
• Publication Date: 2013-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305928
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Looking in</bold>: The penetrating power of high‐energy X‐rays provides a means to monitor in situ and in real time the course of ball‐milling reactions of organic pharmaceutical solids by detecting crystalline phases and assessing the evolution of their particle sizes. Upon switching from neat grinding to liquid‐assisted grinding, cocrystal formation is enabled or tremendously accelerated, while the reaction mechanism alters its course.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6z7k7j" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>