Stereospecific Biosynthesis of β‐Methyltryptophan from L‐Tryptophan Features a Stereochemical Switch1. Issue 49 (25th October 2013) - Zou, Yi
Abstract Make the switch: The three‐enzyme cassette MarG/H/I is responsible for stereospecific biosynthesis of β‐methyltryptophan from L‐tryptophan (1). MarG/I convert 1 into (2S, 3R)‐β‐methyltryptophan, while MarG/I combined with MarH convert 1 into (2S, 3S)‐β‐methyltryptophan. MarH serves as a stereochemical switch by catalyzing the stereoinversion of the β‐stereocenter.