End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation1. Issue 47 (2nd October 2013)

• Record Type: Journal Article
• Authors: Mascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M. B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 47(2013)
• Page Start: 12359
• Page End: 12363
• Publication Date: 2013-10-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305429
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A series of tubes</bold>: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot‐scale plant used a novel route that incorporated many advantages of continuous‐flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t78sb4f" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>