Backbone FCH⋅⋅⋅O Hydrogen Bonds in 2′F‐Substituted Nucleic Acids1. Issue 46 (23rd September 2013)

• Record Type: Journal Article
• Authors: Martin‐Pintado, Nerea; Deleavey, Glen F.; Portella, Guillem; Campos‐Olivas, Ramón; Orozco, Modesto; Damha, Masad J.; González, Carlos
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 46(2013)
• Page Start: 12065
• Page End: 12068
• Publication Date: 2013-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305710
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Polarizing CH⋅⋅⋅O hydrogen bonds</bold>: The structure of oligonucleotides containing alternating and contiguous tracts of 2′F‐RNA and 2′F‐ANA nucleotides reveals that nonconventional FCH⋅⋅⋅O hydrogen bonds have a strong stabilizing effect on 2′‐fluorinated duplexes.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t77rj4m" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>