Catalytic Enantioselective Synthesis of Tertiary Thiols From 5H‐Thiazol‐4‐ones and Nitroolefins: Bifunctional Ureidopeptide‐Based Brønsted Base Catalysis1. Issue 45 (17th September 2013)

• Record Type: Journal Article
• Authors: Diosdado, Saioa; Etxabe, Julen; Izquierdo, Joseba; Landa, Aitor; Mielgo, Antonia; Olaizola, Iurre; López, Rosa; Palomo, Claudio
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 45(2013)
• Page Start: 11846
• Page End: 11851
• Publication Date: 2013-09-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305644
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Fully loaded</bold>: The ureidopeptide‐based bifunctional Brønsted base <bold>1</bold> efficiently promotes the first direct catalytic Michael reaction of α‐mercapto carboxylate surrogates with nitroolefins involving a fully substituted α‐carbon atom construction.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t72qndv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>