Fluorescent‐Ligand‐Mediated Screening of G‐Quadruplex Structures Using a DNA Microarray1. Issue 46 (21st October 2013)

• Record Type: Journal Article
• Authors: Iida, Keisuke; Nakamura, Takahiro; Yoshida, Wataru; Tera, Masayuki; Nakabayashi, Kazuhiko; Hata, Kenichiro; Ikebukuro, Kazunori; Nagasawa, Kazuo
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 46(2013)
• Page Start: 12052
• Page End: 12055
• Publication Date: 2013-10-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305366
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Light up, G‐quadruplexes!</bold> A fast high‐throughput screening for the discovery of novel G‐quadruplex‐forming oligonucleotides (GFOs) has been developed. By using a fluorescent G‐quadruplex ligand and a DNA microarray, 1998 novel GFO candidates in CpG islands were disclosed. (CpG=cytosine‐phosphate‐guanosine).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t77r6p8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>