A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold1. Issue 45 (17th September 2013)

• Record Type: Journal Article
• Authors: Montagner, Diego; Yap, Siew Qi; Ang, Wee Han
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 45(2013)
• Page Start: 11785
• Page End: 11789
• Publication Date: 2013-09-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305734
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Watching closely</bold>: A fluorescent probe was engineered to detect the clinically relevant platinum drug cisplatin within a complex cellular environment, thus providing a direct means for visualizing its cell entry and the activation of platinum(IV) prodrugs in cancer cells.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t72qbn2" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>