Discovery of Chemoselective and Biocompatible Reactions Using a High‐Throughput Immunoassay Screening1. Issue 46 (7th October 2013)

• Record Type: Journal Article
• Authors: Kolodych, Sergii; Rasolofonjatovo, Evelia; Chaumontet, Manon; Nevers, Marie‐Claire; Créminon, Christophe; Taran, Frédéric
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 46(2013)
• Page Start: 12056
• Page End: 12060
• Publication Date: 2013-10-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305645
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>An immunoassay‐based method</bold> was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t77rg2g" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>