Phenylethynylcobalamin: A Light‐Stable and Thermolysis‐Resistant Organometallic Vitamin B12 Derivative Prepared by Radical Synthesis1. Issue 43 (12th September 2013)

• Record Type: Journal Article
• Authors: Ruetz, Markus; Salchner, Robert; Wurst, Klaus; Fedosov, Sergey; Kräutler, Bernhard
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 43(2013)
• Page Start: 11406
• Page End: 11409
• Publication Date: 2013-09-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305206
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Don't take this antivitamin!</bold> 2‐Phenylethynylcobalamin (see picture) was prepared in a newly developed radical reaction using cob(II)alamin and 1‐iodo‐2‐phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light‐stable and heat‐resistant organometallic cobalamin. It is bound well by two important proteins of the human B₁₂ transport system and has properties that are as expected for a new type of an "antivitamin B₁₂".<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3crvtf" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>