Total Synthesis and Biological Evaluation of Jerantinine E1. Issue 50 (14th October 2013)

• Record Type: Journal Article
• Authors: Frei, Reto; Staedler, Davide; Raja, Aruna; Franke, Raimo; Sasse, Florenz; Gerber‐Lemaire, Sandrine; Waser, Jérôme
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 50(2013)
• Page Start: 13373
• Page End: 13376
• Publication Date: 2013-10-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305533
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Nature's beauty</bold>: The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3kjq9w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>