Enhanced Detection of High‐Mass Proteins by Using an Active Pixel Detector1. Issue 43 (3rd September 2013)

• Record Type: Journal Article
• Authors: Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 43(2013)
• Page Start: 11261
• Page End: 11264
• Publication Date: 2013-09-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305501
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Flying high</bold>: Application of an active pixel detector with high charge sensitivity to a linear time‐of‐flight mass spectrometer results in enhanced detection of high‐mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass‐dependent ion‐focusing phenomena (see picture).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3cs8qg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>