Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions1. Issue 46 (23rd September 2013)

• Record Type: Journal Article
• Authors: Schäfer, Gesa; Milić, Jelena; Eldahshan, Adeeb; Götz, Frank; Zühlke, Kerstin; Schillinger, Christian; Kreuchwig, Annika; Elkins, Jonathan M.; Abdul Azeez, Kamal R.; Oder, Andreas; Moutty, Marie C.; Masada, Nanako; Beerbaum, Monika; Schlegel, Brigitte; Niquet, Sylvia; Schmieder, Peter; Krause, Gerd; von Kries, Jens Peter; Cooper, Dermot M. F.; Knapp, Stefan; Rademann, Jörg; Rosenthal, Walter; Klussmann, Enno
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 46(2013)
• Page Start: 12187
• Page End: 12191
• Publication Date: 2013-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304686
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A good fit</bold>: Interactions between A‐kinase anchoring proteins (AKAPs) and protein kinase A (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α‐helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t77rm33" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>