Chemical Synthesis of Mono‐ and Bis‐Labeled Pre‐MicroRNAs1. Issue 46 (23rd September 2013)

• Record Type: Journal Article
• Authors: Pradère, Ugo; Brunschweiger, Andreas; Gebert, Luca F. R.; Lucic, Matije; Roos, Martina; Hall, Jonathan
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 46(2013)
• Page Start: 12028
• Page End: 12032
• Publication Date: 2013-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304986
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A chemical method</bold> for the post‐synthetic labeling of pre‐miRNAs on solid support using easily accessible reagents was developed. The procedure was employed to generate a library of 31 pre‐microRNAs carrying labels commonly used in chemical biology, including Cy3, trioxalen, biotin, and BHQ‐1.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t77rcgj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>