Controlling Biological Activity with Light: Diarylethene‐Containing Cyclic Peptidomimetics1. (19th February 2014)

• Record Type: Journal Article
• Authors: Babii, Oleg; Afonin, Sergii; Berditsch, Marina; Reiβer, Sabine; Mykhailiuk, Pavel K.; Kubyshkin, Vladimir S.; Steinbrecher, Thomas; Ulrich, Anne S.; Komarov, Igor V.
• Is Part Of: Angewandte Chemie. Volume 126:Number 13(2014)
• Page Start: 3460
• Page End: 3463
• Publication Date: 2014-02-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201310019
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Photobiological processes in nature are usually triggered by nonpeptidic chromophores or by modified side chains. A system is presented in which the polypeptide backbone itself can be conformationally switched by light. An amino acid analogue was designed and synthesized based on a reversibly photoisomerizable diarylethene scaffold. This analogue was incorporated into the cyclic backbone of the antimicrobial peptide gramicidin S at several sites. The biological activity of the resulting peptidomimetics could then be effectively controlled by ultraviolet/visible light within strictly defined spatial and temporal limits.</p> </abstract>