Asymmetric Organocatalytic Direct C(sp2)H/C(sp3)H Oxidative Cross‐Coupling by Chiral Iodine Reagents1. (19th February 2014)

• Record Type: Journal Article
• Authors: Wu, Hua; He, Yu‐Ping; Xu, Lue; Zhang, Dong‐Yang; Gong, Liu‐Zhu
• Is Part Of: Angewandte Chemie. Volume 126:Number 13(2014)
• Page Start: 3534
• Page End: 3537
• Publication Date: 2014-02-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201309967
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An asymmetric organocatalytic direct CH/CH oxidative coupling reaction of <italic>N</italic>¹, <italic>N</italic>³‐diphenylmalonamides has been well established by using chiral organoiodine compounds as catalysts, wherein four CH bonds were stereoselectively functionalized to give structurally diverse spirooxindoles with high levels of enantioselectivity. More importantly, the findings indicated that chiral hypervalent organoiodine reagents can serve as alternative catalysts for the creation of enantioselective functionalization of inactive CH bonds.</p> </abstract>