Cascade Reactions in Multicompartmentalized Polymersomes1. (19th November 2013)

• Record Type: Journal Article
• Authors: Peters, Ruud J. R. W.; Marguet, Maïté; Marais, Sébastien; Fraaije, Marco W.; van Hest, Jan C. M.; Lecommandoux, Sébastien
• Is Part Of: Angewandte Chemie. Volume 126:Number 1(2014)
• Page Start: 150
• Page End: 154
• Publication Date: 2013-11-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201308141
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Enzyme‐filled polystyrene‐<italic>b</italic>‐poly(3‐(isocyano‐<sc>L</sc>‐alanyl‐aminoethyl)thiophene) (PS‐<italic>b</italic>‐PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene‐<italic>b</italic>‐poly(ethylene oxide) (PB‐<italic>b</italic>‐PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor‐dependent three‐enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.</p> </abstract>