Copper‐Catalyzed Reduction of Alkyl Triflates and Iodides: An Efficient Method for the Deoxygenation of Primary and Secondary Alcohols1. (4th December 2013)

• Record Type: Journal Article
• Authors: Dang, Hester; Cox, Nick; Lalic, Gojko
• Is Part Of: Angewandte Chemie. Volume 126:Number 3(2014)
• Page Start: 771
• Page End: 775
• Publication Date: 2013-12-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201307697
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We describe an effective method for catalytic reduction of 1° alkyl sulfonates, and 1° and 2° iodides in the presence of a wide range of functional groups. This Cu‐catalyzed reaction provides a means for the effective deoxygenation of alcohols, as demonstrated by the highly selective reduction of 1° alcohols using a triflation/reduction sequence. A preliminary study of the reaction mechanism suggests that the reduction does not involve free‐radical intermediates.</p> </abstract>