Image‐based assessment of microvascular function and structure in collagen XV‐ and XVIII‐deficient mice. (9th December 2013)

• Record Type: Journal Article
• Authors: Rygh, C. B.; Løkka, G.; Heljasvaara, R.; Taxt, T.; Pavlin, T.; Sormunen, R.; Pihlajaniemi, T.; Curry, F. R.; Tenstad, O.; Reed, R. K.
• Is Part Of: Journal of physiology. Volume 592:Number 2(2014:Jan.)
• Page Start: 325
• Page End: 336
• Publication Date: 2013-12-09
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/jphysiol.2013.263574
• Languages: English
• ISSNs: 0022-3751

Abstract

<abstract abstract-type="highlights"> <title>Key points</title> <p> <list id="tjp5970-list-0001" list-type="bullet"> <list-item> <p>Collagen XV and XVIII occur in muscle and connective tissue capillaries and are needed for maintaining a normal circulatory phenotype.</p> </list-item> <list-item> <p>Lack of collagen XV in mice leads to increased vascular permeability, increased extraction fraction, and increased extravascular extracellular space in striated muscle.</p> </list-item> <list-item> <p>Lack of collagen XVIII in mice leads to increased blood flow, permeability, permeability–surface area product and blood–tissue transvascular transfer in striated muscle tissue.</p> </list-item> <list-item> <p>Our results show that functional imaging with MRI and subsequent data analysis provide reliable and robust data and are valuable tools for assessing detailed physiological information non‐invasively.</p> </list-item> </list> </p> </abstract>