Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure. (15th January 2014)

• Record Type: Journal Article
• Authors: Marcus, Noah J.; Del, Rodrigo; Schultz, Evan P.; Xia, Xiao‐Hong; Schultz, Harold D.
• Is Part Of: Journal of physiology. Volume 592:Number 2(2014:Jan.)
• Page Start: 391
• Page End: 408
• Publication Date: 2014-01-15
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/jphysiol.2013.266221
• Languages: English
• ISSNs: 0022-3751

Abstract

<abstract abstract-type="highlights"> <title>Key points</title> <p> <list id="tjp5992-list-0001" list-type="bullet"> <list-item> <p>A strong correlation between disordered breathing patterns, elevated sympathetic nerve activity and enhanced chemoreflex sensitivity exists in patients with heart failure.</p> </list-item> <list-item> <p>Evidence indicates that disordered breathing patterns and increased sympathetic nerve activity increases arrhythmia incidence in patients with heart failure.</p> </list-item> <list-item> <p>Enhanced coupling between sympathetic and respiratory neural drive underlies elevated sympathetic nerve activity in an animal model of sleep apnoea.</p> </list-item> <list-item> <p>We investigated the impact of carotid body chemoreceptor denervation on sympathetic nerve activity, disordered breathing and sympatho‐respiratory coupling in an animal model of heart failure.</p> </list-item> <list-item> <p>Renal sympathetic nerve activity, apnoea/hypopnoea incidence, variability measures of tidal volume and respiratory rate and arrhythmia incidence were quantified during resting breathing in heart failure animals with and without carotid body ablation.</p> </list-item> <list-item> <p>Our results indicate that carotid body chemoreceptor denervation reduces sympathetic nerve activity, disordered breathing patterns, arrhythmia incidence and sympatho‐respiratory coupling in experimental heart failure.</p> </list-item> <list-item> <p>These findings suggest that device‐oriented ablation of carotid body chemoreceptors is a viable treatment option for reduction of sympathetic nerve activity, disordered breathing patterns and arrhythmia incidence in heart failure.</p> </list-item> </list> </p> </abstract>